The Harmony Prenatal Test

What is the Harmony Test?

The harmony test is a new non-invasive prenatal screening test (NIPT) which can be performed from 10 weeks gestation.

The test is a simple blood test taken from the mother which is then analysed for fetal cell-free DNA (cfDNA). cfDNA is the result of the natural breakdown of fetal cells and can be found in the mothers blood. cfDNA can be tested to identify more than 99% of babies with Down’s syndrome (Trisomy 21), 98% of babies with Edwards syndrome (Trisomy 18) and 80% of babies with Patau’s syndrome (Trisomy 13).

iStock_000031093228Small

Why choose the Harmony test?

The Harmony test is now one of the most predictive and accurate non-invasive tests available to predict the chance of your baby having a chromosomal abnormality.

Conventional screening will detect approximately 70-80% of pregnancies with Down’s syndrome.

The Harmony test will detect over 99%.

If the test result shows a low risk result for a chromosomal abnormality, then your baby will have a risk of less than 1 in 10,000.

If the test result shows a high risk result, then the probability that your baby has a chromosomal abnormality is greater than 99%.

A high risk result does not mean your baby definitely has a chromosomal abnormality although it is highly likely. For this reason, an invasive procedure such amniocentesis or chorionic villus sampling (CVS) would be recommended following a high risk Harmony result.

Current screening tests (Nuchal Translucency scan) have a false positive rate (that is, the results suggest a problem when the baby is in fact healthy) of around 4%. The Harmony test has a false positive rate of 0.1%. This reduction in the false positive rate reduces the number of women offered invasive testing, using chorionic villus sampling (CVS) or amniocentesis. Both of these procedures carry around a one in 100 risk of causing a miscarriage.

 

How is the test performed?

An ultrasound scan is always performed prior to your blood test. This will ensure you are at the correct gestation (over 10 weeks).

Your scan and blood test will be discussed and if you wish to proceed we will take your blood sample.

Your blood sample will be packaged and sent the same day to laboratory based in London.

 

Can I find out the Gender of my baby?

The test is primarily used for the detection of Trisomy 21,18 and 13, however you can request X and Y analysis providing over 99% accuracy for your baby’s gender.

This option is also available for twin pregnancies.

A female result for a twin pregnancy will apply to both babies, a male result will apply to either one or both babies.

 

Sex Chromosome conditions

The Harmony test can also assess the risk of sex chromosome conditions XXX, XYY, XXYY, XXY and a missing X chromosome in a girl (Turner Syndrome). This option will be discussed at your appointment to determine whether requesting this is right for you. This option is not available for twin pregnancies.

 

When do I get my results?

The results are typically available in 3-5 working days from receipt of the sample in the laboratory in London.

There is a 3% chance there is insufficient fetal DNA in the sample to provide a result. In this case you will be offered a second blood test at no extra charge.

You will be contacted by telephone when the results have been received at Babyvision. The results will also be posted to you.

 

What is the cost of the Harmony test?

The total cost, inclusive of your scan, and blood test and laboratory fees – £395

 

What do I do after my test?

If you have a low risk result you should still attend your 12 week NHS scan and advise that the Harmony test has been performed.

If you have a high risk result we will inform your booking hospital and arrange a referral for further testing.

 

Are there problems this test will not detect?

Yes. Structural abnormalities for example Spina Bifida and heart defects can not be detected with the Harmony test. You will still be required to attend your 12 and 20 week scans (plus any additional scans which may be arranged for you by your hospital).

Further information can be found by following www.ariosadx.com

Antenatal Results and Choices ARC